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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
1.21
Human Site:
T1076
Identified Species:
2.96
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
T1076
E
T
T
S
G
T
S
T
E
P
V
K
N
S
S
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
D1052
K
D
L
S
L
G
L
D
D
S
R
T
N
T
P
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
A1076
E
T
T
S
G
T
N
A
E
P
V
K
N
S
S
Dog
Lupus familis
XP_548147
1490
164467
V1076
E
T
T
S
G
T
S
V
E
P
V
K
N
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
A1072
E
T
T
S
G
T
T
A
E
P
V
K
N
N
S
Rat
Rattus norvegicus
Q3MJK5
1484
163772
A1072
E
T
T
S
G
T
A
A
E
P
V
K
N
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
E923
R
Q
K
Q
M
P
E
E
L
T
A
P
K
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
V1113
C
G
T
P
T
P
A
V
W
P
S
V
I
K
L
Nematode Worm
Caenorhab. elegans
P46551
730
82410
H367
K
I
L
R
Q
L
H
H
K
N
I
V
R
L
M
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
S901
P
R
E
G
K
D
S
S
S
D
G
G
K
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
13.3
86.6
93.3
N.A.
80
86.6
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
13.3
0
6.6
P-Site Similarity:
100
33.3
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
20
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
20
30
0
0
10
0
0
20
0
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
10
0
10
10
10
0
0
0
0
0
% D
% Glu:
50
0
10
0
0
0
10
10
50
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
10
50
10
0
0
0
0
10
10
0
0
0
% G
% His:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
20
0
10
0
10
0
0
0
10
0
0
50
20
10
0
% K
% Leu:
0
0
20
0
10
10
10
0
10
0
0
0
0
10
10
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
10
0
0
10
0
0
60
10
0
% N
% Pro:
10
0
0
10
0
20
0
0
0
60
0
10
0
0
20
% P
% Gln:
0
10
0
10
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
10
0
10
0
0
0
0
0
0
10
0
10
0
0
% R
% Ser:
0
0
0
60
0
0
30
10
10
10
10
0
0
40
50
% S
% Thr:
0
50
60
0
10
50
10
10
0
10
0
10
0
10
10
% T
% Val:
0
0
0
0
0
0
0
20
0
0
50
20
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _